Abstract
Background:
Wound healing disorders and skin fibrotic lesions (e.g., keloids) are complex clinical
challenges often leading to functional impairments. Hydrogen -rich materials, known for their antioxidant, anti-inflammatory, and metabolic regulatory properties, have emerged as promising therapeutic agents. This study evaluates the effects and molecular mechanisms of hydrogen-rich saline (HRS) and hydrogen-rich water (HRW) in wound repair and scar management.