Jonathan J. Panzer, Mingming Pan, Mrudula Nair, Ian M. Loveless, Indra Adrianto, Ling Huang, Dhananjay Chitale, Christina de Guzman Strong, Albert M. Levin, Lamont R. Jones
BACKGROUND
Keloid disease (KD) is a fibroproliferative disorder of the skin involving abnormal wound healing that leads to excessive scar tissue growth which causes pain, itching, and decreased quality of life. While previous RNA sequencing (RNA-Seq) studies have characterized differential gene expression between keloid and normal skin tissue, no prior studies have evaluated how fibroblast subtype enrichment variability may impact the observed gene expression in the tissue or immune cell responses.
CONCLUSIONS
These findings reveal significant fibroblast subtype enrichment heterogeneity in keloids related to differential immune responses. Further studies are needed to determine whether these keloid subclasses may underly differences in KD progression or varied responses to therapy.
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