Fibroblast Heterogeneity and its Role in Keloid Pathogenesis Implication for targeted drug development
Jong Hee Lee, MD, PhD
BACKGROUND
Keloids are pathological scars resulting from abnormal wound healing. While clinical features vary by anatomical location, the underlying molecular mechanisms contributing to site-specific fibrosis remain poorly understood. Recent research suggests fibroblast heterogeneity and lipid-inflammation signaling play roles in fibrotic disease progression, but their spatial distribution within keloids and therapeutic implications require investigation.
CONCLUSION AND RELEVANCE
Regional tissue microenvironments influence fibroblast fate in keloid disease. Integrated spatial and single-cell transcriptomic profiling identifies site-specific fibroblast programs and suggests potential therapeutic strategies for fibrotic skin disease.
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