The Implications of 3D Culture Models on Keloid Research: A Systematic Review
Trecy Hemedi
BACKGROUND
Treatment responses to keloid lesions vary greatly between patients due to the heterogeneous nature of the disorder. While animal and 2D cell culture models have improved understanding of the underlying mechanisms, they fail to fully replicate the physiological in vivo environment needed for successful therapeutic translation.
Recently, advanced 3D human cell culture models have gained traction to address these gaps. Existing literature highlights limitations in both traditional and 3D approaches, yet lacks a comprehensive summary comparing their relative strengths and weaknesses for modeling keloidogenesis and personalized treatments.
CONCLUSION
Here, we discuss contrast mechanistic outcomes between 3D and 2D in vitro keloid cell culture models, discuss recent contributions of 3D cell culture methods to keloid research and their emerging role in personalized therapies.
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