Multi-antigen Imaging Reveals Inflammatory DC, Adam17 And Neprilysin As Effectors In Keloid Formation
Jürgen Bauerschmitz, Mathias Rath, Alain Pitiot , Michael Kirr, Waltraud Fröhlich, Bianca Plosnita, Stefan Schliep, Andreas S Baur, Christian Ostalecki
Article Type: Conference Abstract
BACKGROUND
Keloid disorder is an aberrant scarring process of the skin, characterized by excessive extracellular matrix synthesis and deposition. The pathogenesis of this prevalent cutaneous disorder is not fully understood; however, a persistent inflammatory process is observed. To obtain more insight into this process, we analyzed lesional, perilesional and healthy tissue using multi-antigen-analysis (MAA) in conjunction with a data mining approach.
CONCLUSION
Our findings provide new insight into the pathogenesis of keloid formation and reveal metalloproteinases as a target for therapeutical intervention.
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