Abstract
BACKGROUND: Currently, there is a need for more effective preventive methods or treatment for hypertrophic scars or keloids. To target important proteins involved in the T helper 2 inflammatory microenvironment and ECM production during scar formation, we designed dual siRNAs targeting interleukin-4 Receptor a (IL-4Ra) and secreted protein acidic and cysteine rich (SPARC) as a novel preventive solution and treatment to reduce pathological scars.
In this study, the effect of dual siRNAs (siIL-4Ra and siSPARC) nanoplex in reducing collagen expression for interleukin-4 stimulated human dermal fibroblasts (HDFs) was investigated
e-treated with fractionated SXRT. The outcome of this re-treatment is now reported.